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Molecular Profile | KIT V560G KIT D816V |
Therapy | Quizartinib |
Indication/Tumor Type | mast cell neoplasm |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KIT V560G KIT D816V | mast cell neoplasm | resistant | Quizartinib | Preclinical | Actionable | In a preclinical study, KIT D816V conferred resistance to Quizartinib in a mast cell line harboring both KIT V560G and KIT D816V in culture (PMID: 23497317). | 23497317 |
PubMed Id | Reference Title | Details |
---|---|---|
(23497317) | Quizartinib (AC220) is a potent second generation class III tyrosine kinase inhibitor that displays a distinct inhibition profile against mutant-FLT3, -PDGFRA and -KIT isoforms. | Full reference... |