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| Molecular Profile | ATM del |
| Therapy | Indisulam |
| Indication/Tumor Type | colorectal cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| ATM del | colorectal cancer | sensitive | Indisulam | Preclinical - Cell culture | Actionable | In a preclinical study, Indisulam (E7070) inhibited viability of a colorectal cancer cell line with knockout of ATM in culture (PMID: 38789724). | 38789724 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (38789724) | A molecular glue RBM39-degrader induces synthetic lethality in cancer cells with homologous recombination repair deficiency. | Full reference... |