Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Molecular Profile | ATM del |
Therapy | Indisulam |
Indication/Tumor Type | colorectal cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ATM del | colorectal cancer | sensitive | Indisulam | Preclinical - Cell culture | Actionable | In a preclinical study, Indisulam (E7070) inhibited viability of a colorectal cancer cell line with knockout of ATM in culture (PMID: 38789724). | 38789724 |
PubMed Id | Reference Title | Details |
---|---|---|
(38789724) | A molecular glue RBM39-degrader induces synthetic lethality in cancer cells with homologous recombination repair deficiency. | Full reference... |