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| Molecular Profile | RET L790F |
| Therapy | Selpercatinib |
| Indication/Tumor Type | medullary thyroid carcinoma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| RET L790F | medullary thyroid carcinoma | predicted - sensitive | Selpercatinib | Case Reports/Case Series | Actionable | In a clinical case study, Retevmo (selpercatinib) treatment resulted in a partial response in a pediatric patient with medullary thyroid carcinoma harboring RET L790F (PMID: 38844796; NCT03336931). | 38844796 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (38844796) | Precision-guided treatment in high-risk pediatric cancers. | Full reference... |