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Molecular Profile | NRAS act mut |
Therapy | BAY 11-7082 |
Indication/Tumor Type | melanoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
NRAS act mut | melanoma | sensitive | BAY 11-7082 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, BAY 11-7082 induced apoptosis and decreased Akt signaling, viability, and colony formation in melanoma cell lines harboring activating NRAS mutations in culture and inhibited tumor growth in a cell line xenograft model (PMID: 38982514). | 38982514 |
PubMed Id | Reference Title | Details |
---|---|---|
(38982514) | IκBα kinase inhibitor BAY 11-7082 promotes anti-tumor effect in RAS-driven cancers. | Full reference... |