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Therapy Name BAY 11-7082
Synonyms
Therapy Description

BAY 11-7082 is an inhibitor of kB kinase (IKK) 1 and 2, which may result in inhibition of NFkappaB pathway signaling leading to cell death (PMID: 23527154, PMID: 32770097).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
BAY 11-7082 BAY117082|BAY11 7082|BAY 117082|BAY11-7821|BAY11 7082|BAY11-7082 BAY 11-7082 is an inhibitor of kB kinase (IKK) 1 and 2, which may result in inhibition of NFkappaB pathway signaling leading to cell death (PMID: 23527154, PMID: 32770097).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
HRAS act mut Advanced Solid Tumor predicted - sensitive BAY 11-7082 Preclinical - Cell line xenograft Actionable In a preclinical study, BAY 11-7082 induced apoptosis and decreased Akt signaling, viability, and colony formation in cancer cells harboring activating HRAS mutations in culture and inhibited tumor growth in a cell line xenograft model (PMID: 38982514). 38982514
NRAS act mut melanoma sensitive BAY 11-7082 Preclinical - Cell line xenograft Actionable In a preclinical study, BAY 11-7082 induced apoptosis and decreased Akt signaling, viability, and colony formation in melanoma cell lines harboring activating NRAS mutations in culture and inhibited tumor growth in a cell line xenograft model (PMID: 38982514). 38982514

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries


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