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Molecular Profile | FGFR3 S249C |
Therapy | R3-altibody |
Indication/Tumor Type | lung squamous cell carcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR3 S249C | lung squamous cell carcinoma | sensitive | R3-altibody | Preclinical - Pdx | Actionable | In a preclinical study, R3-altibody inhibited tumor growth in a patient-derived xenograft (PDX) model of lung squamous cell carcinoma harboring FGFR3 S249C (PMID: 39082679). | 39082679 |
PubMed Id | Reference Title | Details |
---|---|---|
(39082679) | A Tetravalent Bispecific Antibody Selectively Inhibits Diverse FGFR3 Oncogenic Variants. | Full reference... |