Therapy Detail
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| Therapy Name | R3-altibody |
| Synonyms | |
| Therapy Description |
R3-altibody is a tetravalent bispecific antibody targeting FGFR3, which potentially inhibits Fgfr3 dimerization, downstream signaling, and tumor growth (PMID: 39082679). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| R3-altibody | R3 altibody | FGFR3 Antibody 4 | R3-altibody is a tetravalent bispecific antibody targeting FGFR3, which potentially inhibits Fgfr3 dimerization, downstream signaling, and tumor growth (PMID: 39082679). |
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FGFR3 S249C FGFR3 V555L | Advanced Solid Tumor | sensitive | R3-altibody | Preclinical - Cell culture | Actionable | In a preclinical study, R3-altibody inhibited Fgfr3 downstream signaling and growth in a cell line expressing FGFR3 S249C and V555L in culture (PMID: 39082679). | 39082679 |
| FGFR3 S249C | lung squamous cell carcinoma | sensitive | R3-altibody | Preclinical - Pdx | Actionable | In a preclinical study, R3-altibody inhibited tumor growth in a patient-derived xenograft (PDX) model of lung squamous cell carcinoma harboring FGFR3 S249C (PMID: 39082679). | 39082679 |
| FGFR3 S249C | bladder urothelial carcinoma | sensitive | R3-altibody | Preclinical - Cell line xenograft | Actionable | In a preclinical study, R3-altibody inhibited Fgfr3 dimerization and proliferation in a urothelial carcinoma cell line harboring FGFR3 S249C in culture and induced tumor regression in a cell line xenograft model (PMID: 39082679). | 39082679 |
| FGFR3 S249C | Advanced Solid Tumor | sensitive | R3-altibody | Preclinical - Cell culture | Actionable | In a preclinical study, R3-altibody inhibited Fgfr3 dimerization and downstream signaling and decreased proliferation in a cell line expressing FGFR3 S249C in culture (PMID: 39082679). | 39082679 |
| FGFR3 S249C FGFR3 V555M | Advanced Solid Tumor | sensitive | R3-altibody | Preclinical - Cell culture | Actionable | In a preclinical study, R3-altibody inhibited Fgfr3 downstream signaling and growth in a cell line expressing FGFR3 S249C and V555M in culture (PMID: 39082679). | 39082679 |
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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