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| Molecular Profile | SMARCA4 loss |
| Therapy | PRT7732 |
| Indication/Tumor Type | lung cancer |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| SMARCA4 loss | lung cancer | predicted - sensitive | PRT7732 | Preclinical | Actionable | In a preclinical study, PRT7732 inhibited tumor growth in a SMARCA4-deficient lung cancer xenograft model (Cancer Res (2024) 84 (6_Supplement): 4503). | detail... |
| PubMed Id | Reference Title | Details |
|---|---|---|
| Abstract 4503: Preclinical characterization of PRT7732: A highly potent, selective, and orally bioavailable targeted protein degrader of SMARCA2 | Full reference... |