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Profile Name | SMARCA4 loss |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
SMARCA4 loss | Advanced Solid Tumor | not applicable | N/A | Preclinical | Emerging | In a preclinical study, siRNA knockdown of BRM in SMARCA4-deficient tumor cells resulted in decreased growth and viability, suggesting that inhibition of BRM may be a promising therapeutic approach for targeting tumors with SMARCA4 loss (PMID: 23872584). | 23872584 | |
SMARCA4 loss | lung non-small cell carcinoma | sensitive | Tozasertib | Preclinical - Cell culture | Actionable | In a preclinical study, non-small cell lung cancer cell lines with SMARCA4 loss demonstrated increased sensitivity to Tozasertib (VX-680), compared to cell lines expressing wild-type SMARCA4, in culture (Cancer Res July 15 2016 (76) (14 Supplement) LB-318). | detail... | |
SMARCA4 loss | Advanced Solid Tumor | predicted - sensitive | PRT7732 | Preclinical - Cell culture | Actionable | In a preclinical study, PRT7732 inhibited proliferation of SMARCA4-deficient cancer cell lines in culture (Cancer Res (2024) 84 (6_Supplement): 4503). | detail... | |
SMARCA4 loss | lung cancer | predicted - sensitive | PRT7732 | Preclinical | Actionable | In a preclinical study, PRT7732 inhibited tumor growth in a SMARCA4-deficient lung cancer xenograft model (Cancer Res (2024) 84 (6_Supplement): 4503). | detail... |