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Molecular Profile | JAK2 V617F JAK2 L902Q JAK2 E1028K |
Therapy | Geldanamycin |
Indication/Tumor Type | hematologic cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
JAK2 V617F JAK2 L902Q JAK2 E1028K | hematologic cancer | sensitive | Geldanamycin | Preclinical - Cell culture | Actionable | In a preclinical study, Geldanamycin inhibited Stat5 signaling and proliferation in a cell line expressing JAK2 V617F, L902Q, and E1028K in culture (PMID: 39091915). | 39091915 |
PubMed Id | Reference Title | Details |
---|---|---|
(39091915) | Type II mode of JAK2 inhibition and destabilization are potential therapeutic approaches against the ruxolitinib resistance driven myeloproliferative neoplasms. | Full reference... |