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Therapy Name	Geldanamycin
Synonyms
Therapy Description	Geldanamycin binds to and inhibits HSP90, potentially resulting in decreased tumor cell growth and increased tumor cell apoptosis (PMID: 19850405, PMID: 11927289, PMID: 32573272).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
Geldanamycin			HSP90 Inhibitor 35	Geldanamycin binds to and inhibits HSP90, potentially resulting in decreased tumor cell growth and increased tumor cell apoptosis (PMID: 19850405, PMID: 11927289, PMID: 32573272).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
JAK2 V617F	hematologic cancer	sensitive	Geldanamycin	Preclinical - Cell culture	Actionable	In a preclinical study, Geldanamycin inhibited Stat5 signaling and proliferation in a cell line expressing JAK2 V617F in culture (PMID: 39091915).	39091915
JAK2 V617F JAK2 L902Q	hematologic cancer	sensitive	Geldanamycin	Preclinical - Cell culture	Actionable	In a preclinical study, Geldanamycin inhibited Stat5 signaling and proliferation in a cell line expressing JAK2 V617F and L902Q in culture (PMID: 39091915).	39091915
JAK2 V617F JAK2 L902Q JAK2 E1028K	hematologic cancer	sensitive	Geldanamycin	Preclinical - Cell culture	Actionable	In a preclinical study, Geldanamycin inhibited Stat5 signaling and proliferation in a cell line expressing JAK2 V617F, L902Q, and E1028K in culture (PMID: 39091915).	39091915
JAK2 V617F JAK2 L902Q JAK2 R938E	hematologic cancer	sensitive	Geldanamycin	Preclinical - Cell culture	Actionable	In a preclinical study, Geldanamycin inhibited Stat5 signaling and proliferation in a cell line expressing JAK2 V617F, L902Q, and R938E in culture (PMID: 39091915).	39091915
JAK2 V617F JAK2 L902Q JAK2 R947Q	hematologic cancer	sensitive	Geldanamycin	Preclinical - Cell culture	Actionable	In a preclinical study, Geldanamycin inhibited Stat5 signaling and proliferation in a cell line expressing JAK2 V617F, L902Q, and R947Q in culture (PMID: 39091915).	39091915
JAK2 V617F JAK2 L983F	hematologic cancer	sensitive	Geldanamycin	Preclinical - Cell culture	Actionable	In a preclinical study, Geldanamycin inhibited Stat5 signaling and proliferation in a cell line expressing JAK2 V617F and L983F in culture (PMID: 39091915).	39091915
JAK2 V617F JAK2 Q959H JAK2 L983F	hematologic cancer	sensitive	Geldanamycin	Preclinical - Cell culture	Actionable	In a preclinical study, Geldanamycin inhibited Stat5 signaling and proliferation in a cell line expressing JAK2 V617F, L983F, and Q959H in culture (PMID: 39091915).	39091915
JAK2 V617F JAK2 Y931C	hematologic cancer	sensitive	Geldanamycin	Preclinical - Cell culture	Actionable	In a preclinical study, Geldanamycin inhibited Stat5 signaling and proliferation in a cell line expressing JAK2 V617F and Y931C in culture (PMID: 39091915).	39091915

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