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Molecular Profile | BRAF V600E |
Therapy | PD-0325901 + Radiotherapy |
Indication/Tumor Type | glioblastoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600E | glioblastoma | sensitive | PD-0325901 + Radiotherapy | Preclinical - Cell culture | Actionable | In a preclinical study, the combination of PD-0325901 and radiotherapy synergistically inhibited cell growth of glioblastoma cell lines harboring BRAF V600E in culture (PMID: 38714355). | 38714355 |
PubMed Id | Reference Title | Details |
---|---|---|
(38714355) | MEK Inhibition Enhances the Antitumor Effect of Radiotherapy in NF1-Deficient Glioblastoma. | Full reference... |