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Molecular Profile EML4 - ALK
Therapy Crizotinib
Indication/Tumor Type neuroendocrine tumor
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
EML4 - ALK neuroendocrine tumor predicted - sensitive Crizotinib Case Reports/Case Series Actionable In a clinical case study, first-line treatment with Xalkori (crizotinib) resulted in shrinkage of the lung and adrenal gland lesions in a patient with a neuroendocrine tumor, consistent with atypical carcinoid tumor, harboring EML4-ALK (PMID: 30154667). 30154667
PubMed Id Reference Title Details
(30154667) ALK-rearrangement neuroendocrine carcinoma of the lung: a comprehensive study of a rare case series and review of literature. Full reference...