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| Molecular Profile | BRAF class 3 |
| Therapy | Belvarafenib |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | no benefit |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF class 3 | Advanced Solid Tumor | no benefit | Belvarafenib | Phase II | Actionable | In a Phase II trial (TAPISTRY), Belvarafenib (HM95573) treatment did not result in any confirmed objective responses in patients with advanced solid tumors harboring BRAF class III alterations, with a clinical benefit rate of 8.7% (2/23), 34.8% (8/23) with stable disease, a median progression-free survival of 2.0 months, and a median overall survival of 8.2 months (Ann Oncol (2024) 35 (Suppl_2): S498-S499; NCT04589845). | detail... |
| PubMed Id | Reference Title | Details |
|---|---|---|
| 624P Belvarafenib in patients (pts) with BRAF class II or III alteration-positive tumours: TAPISTRY study | Full reference... |