Molecular Profile Detail

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Profile Name BRAF class 3
Gene Variant Detail

BRAF class 3 (loss of function)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF class 3 melanoma predicted - sensitive Exarafenib Preclinical - Cell line xenograft Actionable In a preclinical study, Exarafenib (KIN-2787) treatment led to inhibition of tumor growth in a melanoma cell line xenograft model harboring a BRAF class 3 mutation (J of Clin Oncol 39, no. 15_suppl (May 20, 2021) 3116-3116). detail...
BRAF class 3 Advanced Solid Tumor predicted - sensitive BDTX-4933 Preclinical - Cell culture Actionable In a preclinical study, BDTX-4933 inhibited proliferation of cells expressing a BRAF class 3 mutation in culture (Eur J Cancer (2022), Vol 174, Supplement 1: S86). detail...
BRAF class 3 Advanced Solid Tumor predicted - sensitive Exarafenib Case Reports/Case Series Actionable In a Phase I trial, Exarafenib (KIN-2787) was tolerated and resulted in a partial response in 17.6% (6/34) and stable disease in 23.5% (8/34) of patients with BRAF-driven advanced solid tumors or NRAS-driven melanoma, including a partial response in 1 patient harboring a BRAF class 3 mutation (Cancer Res (2023) 83 (8_Supplement): CT032; NCT04913285). detail...
BRAF class 3 Advanced Solid Tumor predicted - sensitive DCC-3084 Preclinical - Cell culture Actionable In a preclinical study, DCC-3084 inhibited downstream signaling and proliferation in cells expressing a BRAF class 3 mutation in culture (Cancer Res (2023) 83 (7_Supplement): 4045). detail...
BRAF class 3 Advanced Solid Tumor no benefit Belvarafenib Phase II Actionable In a Phase II trial (TAPISTRY), Belvarafenib (HM95573) treatment did not result in any confirmed objective responses in patients with advanced solid tumors harboring BRAF class III alterations, with a clinical benefit rate of 8.7% (2/23), 34.8% (8/23) with stable disease, a median progression-free survival of 2.0 months, and a median overall survival of 8.2 months (Ann Oncol (2024) 35 (Suppl_2): S498-S499; NCT04589845). detail...