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Molecular Profile | KIT act mut |
Therapy | Regorafenib |
Indication/Tumor Type | melanoma |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KIT act mut | melanoma | predicted - sensitive | Regorafenib | Case Reports/Case Series | Actionable | In a clinical case study, Stivarga (regorafenib) treatment demonstrated safety and preliminary activity in patients with melanoma harboring activating mutations in KIT, resulting in an overall response rate of 100% (7/7, 1 complete and 6 partial responses), with median duration of response and median progression-free survival not reached and response ongoing in 4 patients at a median follow-up of 43 weeks (Ann Oncol (2024) 35 (suppl_2): S743-S744). | detail... |
PubMed Id | Reference Title | Details |
---|---|---|
1132P Regorafenib in Caucasian patients with pretreated advanced KIT-mutant melanoma: A dual center case series | Full reference... |