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Molecular Profile ATM inact mut
Therapy Durvalumab + Olaparib
Indication/Tumor Type neuroendocrine carcinoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ATM inact mut neuroendocrine carcinoma predicted - sensitive Durvalumab + Olaparib Case Reports/Case Series Actionable In a Phase II trial, treatment with the combination of Lynparza (olaparib) and Imfinzi (durvalumab) resulted in a partial response in a patient with a neuroendocrine carcinoma harboring an ATM inactivating mutation (PMID: 37365284). 37365284
PubMed Id Reference Title Details
(37365284) A signal-seeking Phase 2 study of olaparib and durvalumab in advanced solid cancers with homologous recombination repair gene alterations. Full reference...