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| Molecular Profile | ATM inact mut |
| Therapy | RP-3500 |
| Indication/Tumor Type | pancreatic cancer |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| ATM inact mut | pancreatic cancer | predicted - sensitive | RP-3500 | Case Reports/Case Series | Actionable | In a Phase I/II trial (TRESR), RP-3500 treatment resulted in a partial response at week 54 in a patient with advanced pancreatic cancer harboring a germline ATM frameshift mutation (PMID: 37277454; NCT04497116). | 37277454 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (37277454) | Camonsertib in DNA damage response-deficient advanced solid tumors: phase 1 trial results. | Full reference... |