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Molecular Profile | ATM inact mut |
Therapy | RP-3500 |
Indication/Tumor Type | lung non-small cell carcinoma |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ATM inact mut | lung non-small cell carcinoma | predicted - sensitive | RP-3500 | Case Reports/Case Series | Actionable | In a Phase I/II trial (TRESR), RP-3500 treatment resulted in a partial response after 37 weeks of treatment in a patient with advanced non-small cell lung cancer harboring germline biallelic ATM inactivation (PMID: 37277454; NCT04497116). | 37277454 |
PubMed Id | Reference Title | Details |
---|---|---|
(37277454) | Camonsertib in DNA damage response-deficient advanced solid tumors: phase 1 trial results. | Full reference... |