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Molecular Profile | PIK3CA E545K |
Therapy | ZM-PI05 |
Indication/Tumor Type | breast cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PIK3CA E545K | breast cancer | sensitive | ZM-PI05 | Preclinical - Cell culture | Actionable | In a preclinical study, ZM-PI05 decreased viability of a breast cancer cell line harboring PIK3CA E545K in culture (PMID: 38986734). | 38986734 |
PubMed Id | Reference Title | Details |
---|---|---|
(38986734) | PI3K PROTAC overcomes the lapatinib resistance in PIK3CA-mutant HER2 positive breast cancer. | Full reference... |