Therapy Detail
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| Therapy Name | ZM-PI05 |
| Synonyms | |
| Therapy Description |
ZM-PI05 is a proteolysis-targeting chimera (PROTAC) targeting PI3K, which potentially degrades Pik3ca and Pik3r1 and inhibits proliferation and tumor growth (PMID: 38986734). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| ZM-PI05 | ZM PI05|ZMPI05 | PI3K Inhibitor (Pan) 42 | ZM-PI05 is a proteolysis-targeting chimera (PROTAC) targeting PI3K, which potentially degrades Pik3ca and Pik3r1 and inhibits proliferation and tumor growth (PMID: 38986734). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PIK3CA E545K | breast cancer | sensitive | ZM-PI05 | Preclinical - Cell culture | Actionable | In a preclinical study, ZM-PI05 decreased viability of a breast cancer cell line harboring PIK3CA E545K in culture (PMID: 38986734). | 38986734 |
| PIK3CA H1047R | Her2-receptor positive breast cancer | sensitive | ZM-PI05 | Preclinical - Cell culture | Actionable | In a preclinical study, ZM-PI05 induced cell cycle arrest and decreased viability of ERBB2 (HER2)-positive breast cancer cell lines harboring PIK3CA H1047R in culture (PMID: 38986734). | 38986734 |
| PIK3CA C420R | Her2-receptor positive breast cancer | sensitive | ZM-PI05 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, ZM-PI05 induced cell cycle arrest and decreased viability of an ERBB2 (HER2)-positive breast cancer cell line harboring PIK3CA C420R in culture and inhibited tumor growth in a cell line xenograft model (PMID: 38986734). | 38986734 |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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