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| Molecular Profile | ERBB3 positive |
| Therapy | DB-1310 |
| Indication/Tumor Type | colon cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| ERBB3 positive | colon cancer | sensitive | DB-1310 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, DB-1310 inhibited tumor growth in an ERBB3 (HER3)-positive colon cancer cell line xenograft model (PMID: 38632563). | 38632563 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (38632563) | DB-1310, an ADC comprised of a novel anti-HER3 antibody conjugated to a DNA topoisomerase I inhibitor, is highly effective for the treatment of HER3-positive solid tumors. | Full reference... |