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| Therapy Name | DB-1310 |
| Synonyms | |
| Therapy Description |
DB-1310 is an antibody-drug conjugate (ADC) comprising an antibody targeting ERBB3 (HER3) linked to a DNA topoisomerase I inhibitor, which potentially inhibits growth of ERBB3 (HER3)-expressing tumors (PMID: 38632563). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| DB-1310 | DB1310|DB 1310 | HER3 (ERBB3) Antibody 30 | DB-1310 is an antibody-drug conjugate (ADC) comprising an antibody targeting ERBB3 (HER3) linked to a DNA topoisomerase I inhibitor, which potentially inhibits growth of ERBB3 (HER3)-expressing tumors (PMID: 38632563). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| ERBB3 positive | colon cancer | sensitive | DB-1310 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, DB-1310 inhibited tumor growth in an ERBB3 (HER3)-positive colon cancer cell line xenograft model (PMID: 38632563). | 38632563 |
| ERBB3 positive | prostate cancer | sensitive | DB-1310 | Preclinical - Pdx | Actionable | In a preclinical study, DB-1310 inhibited tumor growth in ERBB3 (HER3)-positive prostate cancer patient-derived xenograft (PDX) models (PMID: 38632563). | 38632563 |
| ERBB3 positive | lung non-small cell carcinoma | sensitive | DB-1310 | Preclinical - Pdx | Actionable | In a preclinical study, DB-1310 inhibited tumor growth in ERBB3 (HER3)-positive non-small cell lung cancer cell line xenograft and patient-derived xenograft (PDX) models (PMID: 38632563). | 38632563 |
| ERBB3 positive | breast cancer | predicted - sensitive | DB-1310 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, DB-1310 inhibited tumor growth in an ERBB3 (HER3)-positive breast cancer cell line xenograft model (PMID: 38632563). | 38632563 |
Filtering
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- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05785741 | Phase Ib/II | DB-1310 + Osimertinib Capecitabine + DB-1310 DB-1310 DB-1310 + Trastuzumab | A Study of DB-1310 in Advanced/Metastatic Solid Tumors | Recruiting | USA | 1 |
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