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| Molecular Profile | RET C634W |
| Therapy | SY-5007 |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| RET C634W | Advanced Solid Tumor | sensitive | SY-5007 | Preclinical - Cell culture | Actionable | In a preclinical study, SY-5007 inhibited proliferation in cells expressing RET C634W in culture (PMID: 39489747). | 39489747 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (39489747) | First-in-human, phase 1 dose-escalation and dose-expansion study of a RET inhibitor SY-5007 in patients with advanced RET-altered solid tumors. | Full reference... |