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Therapy Name SY-5007
Synonyms
Therapy Description

SY-5007 is a RET inhibitor with activity against resistance mutations including M918T, G810S, and V804M, which potentially decreases tumor cell proliferation and tumor growth (PMID: 39489747).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
SY-5007 SY5007|SY 5007 RET Inhibitor 53 SY-5007 is a RET inhibitor with activity against resistance mutations including M918T, G810S, and V804M, which potentially decreases tumor cell proliferation and tumor growth (PMID: 39489747).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET C634W Advanced Solid Tumor sensitive SY-5007 Preclinical - Cell culture Actionable In a preclinical study, SY-5007 inhibited proliferation in cells expressing RET C634W in culture (PMID: 39489747). 39489747
RET fusion lung non-small cell carcinoma sensitive SY-5007 Phase I Actionable In a Phase I trial, SY-5007 therapy was tolerable and led to an objective response rate (ORR) of 57.8% (67/116, 67 partial responses), disease control rate (DCR) of 95.7% (111/116), and median progression-free survival of 21.1 mo in advanced solid tumor patients with RET fusions or alterations, and an ORR of 64.1% (41/64) and DCR of 96.9% (62/64) at the phase II dose in non-small cell lung cancer patients with KIF5B (n=51), CCDC6 (n=12), NCOA4 (n=1), or other RET fusions (n=4) (PMID: 39489747; NCT05278364). 39489747
RET M918T medullary thyroid carcinoma sensitive SY-5007 Phase I Actionable In a Phase I trial, SY-5007 treatment demonstrated safety and resulted in an objective response rate (ORR) of 57.8% (67/116, partial responses), a disease control rate (DCR) of 95.7% (111/116), and a median progression-free survival of 21.1 mo in advanced solid tumor patients harboring RET fusions or alterations, with an ORR of 52.2% (12/23) and DCR of 91.3% (21/23) at the phase II dose in medullary thyroid cancer patients harboring RET M918T (n=15) or other mutations (n=8) (PMID: 39489747; NCT05278364). 39489747

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries


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