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Molecular Profile JAK3 Q988P
Therapy Ruxolitinib
Indication/Tumor Type hematologic cancer
Response Type decreased response

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
JAK3 Q988P hematologic cancer decreased response Ruxolitinib Preclinical - Cell culture Actionable In a preclinical study, transformed cells expressing JAK3 Q988P were less sensitive to Jakafi (ruxolitinib) treatment compared to cells expressing JAK3 M511I in culture (PMID: 37712558). 37712558
PubMed Id Reference Title Details
(37712558) The JAK3Q988P mutation reveals oncogenic potential and resistance to ruxolitinib. Full reference...