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| Molecular Profile | JAK3 Q988P |
| Therapy | Ruxolitinib |
| Indication/Tumor Type | hematologic cancer |
| Response Type | decreased response |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| JAK3 Q988P | hematologic cancer | decreased response | Ruxolitinib | Preclinical - Cell culture | Actionable | In a preclinical study, transformed cells expressing JAK3 Q988P were less sensitive to Jakafi (ruxolitinib) treatment compared to cells expressing JAK3 M511I in culture (PMID: 37712558). | 37712558 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (37712558) | The JAK3Q988P mutation reveals oncogenic potential and resistance to ruxolitinib. | Full reference... |