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Molecular Profile | KIT D816_N822delinsMIDSI |
Therapy | Avapritinib |
Indication/Tumor Type | systemic mastocytosis |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KIT D816_N822delinsMIDSI | systemic mastocytosis | predicted - sensitive | Avapritinib | Case Reports/Case Series | Actionable | In a clinical case study, Ayvakit (avapritinib) treatment resulted in improved symptoms, reduced tryptase levels, and reduced lymphadenopathy in a patient with systemic mastocytosis harboring KIT D816_N822delinsMIDSI (PMID: 38273969). | 38273969 |
PubMed Id | Reference Title | Details |
---|---|---|
(38273969) | Avapritinib treatment of aggressive systemic mastocytosis with a novel KIT exon 17 mutation. | Full reference... |