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Molecular Profile BRAF F595L
Therapy Cetuximab + Trametinib
Indication/Tumor Type intrahepatic cholangiocarcinoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF F595L intrahepatic cholangiocarcinoma predicted - sensitive Cetuximab + Trametinib Case Reports/Case Series Actionable In a clinical case study, treatment with the combination of Erbitux (cetuximab) and Mekinist (trametinib) followed by Erbitux (cetuximab) monotherapy resulted in an objective response at a follow-up of 6 months in a patient with intrahepatic cholangiocarcinoma harboring BRAF F595L along with an IDH2 R172W (PMID: 39516363). 39516363
PubMed Id Reference Title Details
(39516363) Therapeutic vulnerabilities and pan-cancer landscape of BRAF class III mutations in epithelial solid tumors. Full reference...