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Molecular Profile JAK3 V718L
Therapy Fedratinib
Indication/Tumor Type esophagus adenocarcinoma
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
JAK3 V718L esophagus adenocarcinoma sensitive Fedratinib Preclinical - Patient cell culture Actionable In a preclinical study, Inrebic (fedratinib) inhibited viability of cells derived from the brain metastases of a patient with esophagus adenocarcinoma harboring JAK3 V718L in culture (PMID: 38985431). 38985431
PubMed Id Reference Title Details
(38985431) A clinically compatible in vitro drug-screening platform identifies therapeutic vulnerabilities in primary cultures of brain metastases. Full reference...