Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
| Molecular Profile | NTRK1 dec exp NTRK2 dec exp |
| Therapy | AZD7451 |
| Indication/Tumor Type | pulmonary large cell neuroendocrine carcinoma |
| Response Type | no benefit |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| NTRK1 dec exp NTRK2 dec exp | pulmonary large cell neuroendocrine carcinoma | no benefit | AZD7451 | Preclinical | Actionable | In a preclinical study, AZD7451 treatment did not inhibit proliferation of a lung large-cell neuroendocrine carcinoma cell line with reduced Ntrk1 and Ntrk2 expression level in culture (PMID: 25054037). | 25054037 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (25054037) | Investigation of neurotrophic tyrosine kinase receptor 1 fusions and neurotrophic tyrosine kinase receptor family expression in non-small-cell lung cancer and sensitivity to AZD7451 in vitro. | Full reference... |