Molecular Profile Detail

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Profile Name NTRK1 dec exp NTRK2 dec exp
Gene Variant Detail

NTRK1 dec exp (no effect)

NTRK2 dec exp (no effect)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
NTRK1 dec exp NTRK2 dec exp pulmonary large cell neuroendocrine carcinoma no benefit AZD7451 Preclinical Actionable In a preclinical study, AZD7451 treatment did not inhibit proliferation of a lung large-cell neuroendocrine carcinoma cell line with reduced Ntrk1 and Ntrk2 expression level in culture (PMID: 25054037). 25054037