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| Molecular Profile | NTRK2 R734C |
| Therapy | AZD6918 |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| NTRK2 R734C | Advanced Solid Tumor | resistant | AZD6918 | Preclinical | Actionable | In a preclinical study, a transformed cell line expressing NTRK2 R734C was resistant to inhibition of Ntrk2 autophosphorylation and BDNF-induced cell proliferation by AZD6918 treatment in culture (PMID: 21242122). | 21242122 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (21242122) | Role and relevance of TrkB mutations and expression in non-small cell lung cancer. | Full reference... |