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Therapy Name AZD6918
Synonyms
Therapy Description

AZD6918 is a selective TRK receptor inhibitor, which potentially leads to increased tumor cell death (PMID: 25700942, PMID: 28230291).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
AZD6918 Trk Receptor Inhibitor (Pan) 33 AZD6918 is a selective TRK receptor inhibitor, which potentially leads to increased tumor cell death (PMID: 25700942, PMID: 28230291).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NTRK2 wild-type Advanced Solid Tumor sensitive AZD6918 Preclinical Actionable In a preclinical study, AZD6918 treatment inhibited Ntrk2 autophosphorylation and BDNF-induced cell proliferation of transformed cell lines expressing wild-type Ntrk2 in culture (PMID: 21242122). 21242122
NTRK2 R734C Advanced Solid Tumor resistant AZD6918 Preclinical Actionable In a preclinical study, a transformed cell line expressing NTRK2 R734C was resistant to inhibition of Ntrk2 autophosphorylation and BDNF-induced cell proliferation by AZD6918 treatment in culture (PMID: 21242122). 21242122
NTRK2 M713I Advanced Solid Tumor resistant AZD6918 Preclinical Actionable In a preclinical study, a transformed cell line expressing NTRK2 M713I was resistant to inhibition of Ntrk2 autophosphorylation and BDNF-induced cell proliferation by AZD6918 treatment in culture (PMID: 21242122). 21242122
NTRK2 R715G Advanced Solid Tumor resistant AZD6918 Preclinical Actionable In a preclinical study, a transformed cell line expressing NTRK2 R715G was resistant to inhibition of Ntrk2 autophosphorylation and BDNF-induced cell proliferation by AZD6918 treatment in culture (PMID: 21242122). 21242122

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries


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