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Molecular Profile | NRAS Q61R |
Therapy | ZT-12-037-01 |
Indication/Tumor Type | melanoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
NRAS Q61R | melanoma | sensitive | ZT-12-037-01 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, ZT-12-037-01 treatment induced apoptosis and inhibited cell proliferation and colony formation in culture and reduced tumor growth and increased survival in cell line xenograft models of melanoma harboring NRAS Q61R (PMID: 30712867). | 30712867 |
PubMed Id | Reference Title | Details |
---|---|---|
(30712867) | Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis. | Full reference... |