Therapy Detail
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| Therapy Name | ZT-12-037-01 |
| Synonyms | |
| Therapy Description |
ZT-12-037-01 is an ATP-competitive small molecule inhibitor, which inhibits the kinase activity of STK19, potentially resulting in increased apoptosis and reduced tumor growth (PMID: 30712867). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| ZT-12-037-01 | EX-A3169 | ZT-12-037-01 is an ATP-competitive small molecule inhibitor, which inhibits the kinase activity of STK19, potentially resulting in increased apoptosis and reduced tumor growth (PMID: 30712867). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| NRAS Q61R | melanoma | sensitive | ZT-12-037-01 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, ZT-12-037-01 treatment induced apoptosis and inhibited cell proliferation and colony formation in culture and reduced tumor growth and increased survival in cell line xenograft models of melanoma harboring NRAS Q61R (PMID: 30712867). | 30712867 |
| BRAF V600E | melanoma | decreased response | ZT-12-037-01 | Preclinical - Cell culture | Actionable | In a preclinical study, melanoma cell lines harboring BRAF V600E demonstrated reduced inhibition of cell proliferation and induction of apoptosis compared to cells harboring NRAS Q61R in culture when treated with ZT-12-037-01 (PMID: 30712867). | 30712867 |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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