Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Molecular Profile | BRAF V600E |
Therapy | ZT-12-037-01 |
Indication/Tumor Type | melanoma |
Response Type | decreased response |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600E | melanoma | decreased response | ZT-12-037-01 | Preclinical - Cell culture | Actionable | In a preclinical study, melanoma cell lines harboring BRAF V600E demonstrated reduced inhibition of cell proliferation and induction of apoptosis compared to cells harboring NRAS Q61R in culture when treated with ZT-12-037-01 (PMID: 30712867). | 30712867 |
PubMed Id | Reference Title | Details |
---|---|---|
(30712867) | Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis. | Full reference... |