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| Molecular Profile | TP53 R248Q |
| Therapy | ReACp53 |
| Indication/Tumor Type | ovarian cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| TP53 R248Q | ovarian cancer | sensitive | ReACp53 | Preclinical - Pdx & cell culture | Actionable | In a preclinical study, ReACp53 rescued p53 activity and decreased viability of ovarian cancer cells harboring TP53 R248Q in culture, and induced tumor regression in patient-derived ovarian cancer xenograft models harboring TP53 R248Q (PMID: 26748848). | 26748848 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (26748848) | A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas. | Full reference... |