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Molecular Profile | ALK amp |
Therapy | hALK.CAR T cells |
Indication/Tumor Type | neuroblastoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ALK amp | neuroblastoma | sensitive | hALK.CAR T cells | Preclinical - Cell line xenograft | Actionable | In a preclinical study, co-culture with hALK.CAR T cells induced killing of neuroblastoma cells with ALK amplification in culture and inhibited tumor growth and improved tumor-free survival in a cell line xenograft model (PMID: 38039964). | 38039964 |
PubMed Id | Reference Title | Details |
---|---|---|
(38039964) | ALK inhibitors increase ALK expression and sensitize neuroblastoma cells to ALK.CAR-T cells. | Full reference... |