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Therapy Name hALK.CAR T cells
Synonyms
Therapy Description

hALK.CAR T cells are T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting ALK linked to the CD8 alpha hinge and transmembrane domain, CD28 costimulatory domain, and CD3zeta signaling domain, which potentially induces cytoxicity against tumor cells with high Alk expression (PMID: 38039964).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
hALK.CAR T cells hALK.CAR T cells are T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting ALK linked to the CD8 alpha hinge and transmembrane domain, CD28 costimulatory domain, and CD3zeta signaling domain, which potentially induces cytoxicity against tumor cells with high Alk expression (PMID: 38039964).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ALK F1245C neuroblastoma sensitive hALK.CAR T cells Preclinical - Patient cell culture Actionable In a preclinical study, co-culture with hALK.CAR T cells induced killing of cells derived from a patient-derived xenograft (PDX) model of neuroblastoma harboring ALK F1245C in culture (PMID: 38039964). 38039964
ALK F1174L neuroblastoma sensitive hALK.CAR T cells Preclinical - Cell culture Actionable In a preclinical study, co-culture with hALK.CAR T cells induced killing of neuroblastoma cells harboring ALK F1174L in culture (PMID: 38039964). 38039964
ALK amp neuroblastoma sensitive hALK.CAR T cells Preclinical - Cell line xenograft Actionable In a preclinical study, co-culture with hALK.CAR T cells induced killing of neuroblastoma cells with ALK amplification in culture and inhibited tumor growth and improved tumor-free survival in a cell line xenograft model (PMID: 38039964). 38039964
ALK R1275Q neuroblastoma sensitive hALK.CAR T cells Preclinical - Cell culture Actionable In a preclinical study, co-culture with hALK.CAR T cells induced killing of neuroblastoma cells harboring ALK R1275Q in culture (PMID: 38039964). 38039964

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06803875 Phase Ib/II hALK.CAR T cells Study of HALK.CAR T Cells for Patients with Relapsed/refractory High-risk Neuroblastoma Not yet recruiting USA 0


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