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Molecular Profile | KIT positive |
Therapy | NN3201 |
Indication/Tumor Type | lung small cell carcinoma |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KIT positive | lung small cell carcinoma | predicted - sensitive | NN3201 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, NN3201 induced cytotoxicity and cell cycle arrest in KIT-positive small cell lung cancer cell lines in culture, and inhibited tumor growth in a cell line xenograft model (Cancer Res (2024) 84 (6_Supplement): 3142). | detail... |
PubMed Id | Reference Title | Details |
---|---|---|
Abstract 3142: NN3201, a novel c-Kit targeting ADC, exhibits robust preclinical anti-tumor efficacy in SCLC and GIST models | Full reference... |