Therapy Detail
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| Therapy Name | NN3201 |
| Synonyms | |
| Therapy Description |
NN3201 is an antibody-drug conjugate (ADC) comprising an antibody targeting KIT linked to monomethyl auristatin E (MMAE), which potentially induces cytotoxicity against KIT-expressing tumor cells and inhibits tumor growth (Cancer Res (2024) 84 (6_Supplement): 3142). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| NN3201 | NN 3201|NN-3201 | NN3201 is an antibody-drug conjugate (ADC) comprising an antibody targeting KIT linked to monomethyl auristatin E (MMAE), which potentially induces cytotoxicity against KIT-expressing tumor cells and inhibits tumor growth (Cancer Res (2024) 84 (6_Supplement): 3142). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KIT positive | lung small cell carcinoma | predicted - sensitive | NN3201 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, NN3201 induced cytotoxicity and cell cycle arrest in KIT-positive small cell lung cancer cell lines in culture, and inhibited tumor growth in a cell line xenograft model (Cancer Res (2024) 84 (6_Supplement): 3142). | detail... |
| KIT positive | gastrointestinal stromal tumor | predicted - sensitive | NN3201 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, NN3201 induced cytotoxicity and cell cycle arrest in KIT-positive gastrointestinal stromal tumor cell lines in culture, and inhibited tumor growth in a cell line xenograft model (Cancer Res (2024) 84 (6_Supplement): 3142). | detail... |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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