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Therapy Detail
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| Therapy Name | NN3201 |
| Synonyms | |
| Therapy Description |
NN3201 is an antibody-drug conjugate (ADC) comprising an antibody targeting KIT linked to monomethyl auristatin E (MMAE), which potentially induces cytotoxicity against KIT-expressing tumor cells and inhibits tumor growth (Cancer Res (2024) 84 (6_Supplement): 3142). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| NN3201 | NN 3201|NN-3201 | NN3201 is an antibody-drug conjugate (ADC) comprising an antibody targeting KIT linked to monomethyl auristatin E (MMAE), which potentially induces cytotoxicity against KIT-expressing tumor cells and inhibits tumor growth (Cancer Res (2024) 84 (6_Supplement): 3142). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KIT positive | lung small cell carcinoma | predicted - sensitive | NN3201 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, NN3201 induced cytotoxicity and cell cycle arrest in KIT-positive small cell lung cancer cell lines in culture, and inhibited tumor growth in a cell line xenograft model (Cancer Res (2024) 84 (6_Supplement): 3142). | detail... |
| KIT positive | gastrointestinal stromal tumor | predicted - sensitive | NN3201 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, NN3201 induced cytotoxicity and cell cycle arrest in KIT-positive gastrointestinal stromal tumor cell lines in culture, and inhibited tumor growth in a cell line xenograft model (Cancer Res (2024) 84 (6_Supplement): 3142). | detail... |
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06805825 | Phase I | NN3201 | A Study of the C-Kit Specific Antibody-Drug Conjugate NN3201 for Advanced And/or Metastatic Solid Tumors Known to Express C-Kit | Recruiting | USA | 0 |
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