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Molecular Profile PMS2 negative
Therapy Pembrolizumab
Indication/Tumor Type ethmoid sinus cancer
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PMS2 negative ethmoid sinus cancer sensitive Pembrolizumab Guideline Actionable Keytruda (pembrolizumab) is included in guidelines as first- and subsequent-line therapy for patients with mismatch repair deficient (dMMR, often defined by the loss of MLH1, PMS2, MSH2, or MSH6 expression by IHC) recurrent, unresectable, or metastatic ethmid sinus cancer (NCCN.org). detail...
PubMed Id Reference Title Details
NCCN.org Full reference...