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| Molecular Profile | JAK2 R683G JAK2 G993A |
| Therapy | CHZ868 |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| JAK2 R683G JAK2 G993A | Advanced Solid Tumor | resistant | CHZ868 | Preclinical - Cell culture | Actionable | In a preclinical study, a cell line expressing JAK2 R683G and G993A was resistant to CHZ868 in culture (PMID: 37290440). | 37290440 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (37290440) | New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation. | Full reference... |