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Therapy Name	CHZ868
Synonyms
Therapy Description	CHZ868 is a type II JAK2 inhibitor, which stabilizes JAK2 in the inactive conformation resulting in decreased downstream signaling and potentially leading to decreased tumor cell growth (PMID: 26175413, PMID: 30498775).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
CHZ868			JAK2 Inhibitor 19	CHZ868 is a type II JAK2 inhibitor, which stabilizes JAK2 in the inactive conformation resulting in decreased downstream signaling and potentially leading to decreased tumor cell growth (PMID: 26175413, PMID: 30498775).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
JAK2 R683G	Advanced Solid Tumor	sensitive	CHZ868	Preclinical - Cell culture	Actionable	In a preclinical study, CHZ868 inhibited viability of a cell line expressing JAK2 R683G in culture (PMID: 37290440).	37290440
JAK2 R683G JAK2 G993A	Advanced Solid Tumor	resistant	CHZ868	Preclinical - Cell culture	Actionable	In a preclinical study, a cell line expressing JAK2 R683G and G993A was resistant to CHZ868 in culture (PMID: 37290440).	37290440
JAK2 R683G JAK2 L884P	Advanced Solid Tumor	resistant	CHZ868	Preclinical - Cell culture	Actionable	In a preclinical study, a cell line expressing JAK2 R683G and L884P was resistant to CHZ868 in culture (PMID: 37290440).	37290440
JAK2 V617F	hematologic cancer	sensitive	CHZ868	Preclinical - Cell culture	Actionable	In a preclinical study, CHZ868 inhibited Stat5 signaling and proliferation in a cell line expressing JAK2 V617F in culture (PMID: 39091915).	39091915
JAK2 V617F	Advanced Solid Tumor	sensitive	CHZ868	Preclinical - Cell culture	Actionable	In a preclinical study, CHZ868 inhibited viability of a cell line expressing JAK2 V617F in culture (PMID: 37290440).	37290440
JAK2 V617F JAK2 G993A	Advanced Solid Tumor	resistant	CHZ868	Preclinical - Cell culture	Actionable	In a preclinical study, a cell line expressing JAK2 V617F and G993A was resistant to CHZ868 in culture (PMID: 37290440).	37290440
JAK2 V617F JAK2 L902Q	hematologic cancer	sensitive	CHZ868	Preclinical - Cell culture	Actionable	In a preclinical study, CHZ868 inhibited Stat5 signaling and proliferation in a cell line expressing JAK2 V617F and L902Q in culture (PMID: 39091915).	39091915
JAK2 V617F JAK2 L983F	hematologic cancer	sensitive	CHZ868	Preclinical - Cell culture	Actionable	In a preclinical study, CHZ868 inhibited Stat5 signaling and proliferation in a cell line expressing JAK2 V617F and L983F in culture (PMID: 39091915).	39091915
JAK2 V617F JAK2 Y931C	hematologic cancer	decreased response	CHZ868	Preclinical - Cell culture	Actionable	In a preclinical study, a cell line expressing JAK2 V617F and Y931C was less sensitive to CHZ868 treatment than cells expressing JAK2 V617F alone in culture (PMID: 39091915).	39091915
JAK2 V617F	bone marrow cancer	sensitive	CHZ868	Preclinical	Actionable	In a preclinical study, CHZ868 inhibited proliferation of myeloproliferative neoplasm cells harboring JAK2 V617F , including cells with decreased response to Type I JAK inhibitors following chronic exposure, and decreased mutant allele burden in a mouse polycythemia vera model expressing JAK2 V617F (PMID: 26175413).	26175413

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