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| Molecular Profile | PDGFRB D850Y |
| Therapy | Imatinib |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | predicted - resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PDGFRB D850Y | Advanced Solid Tumor | predicted - resistant | Imatinib | Preclinical - Biochemical | Actionable | In a preclinical study, PDGFRB D850Y demonstrated resistance to inhibition of Pdgfrb activity by Gleevec (imatinib) treatment in a reporter assay in cultured cells (PMID: 39580648). | 39580648 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (39580648) | A germline PDGFRB splice site variant associated with infantile myofibromatosis and resistance to imatinib. | Full reference... |