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| Profile Name | PDGFRB D850Y |
| Gene Variant Detail | |
| Relevant Treatment Approaches | PDGFR Inhibitor (Pan) PDGFR-beta Inhibitor |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| PDGFRB D850Y | Advanced Solid Tumor | predicted - resistant | PDGFR Inhibitor (Pan) | Imatinib | Preclinical - Biochemical | Actionable | In a preclinical study, PDGFRB D850Y demonstrated resistance to inhibition of Pdgfrb activity by Gleevec (imatinib) treatment in a reporter assay in cultured cells (PMID: 39580648). | 39580648 |
| PDGFRB D850Y | Advanced Solid Tumor | predicted - sensitive | PDGFR Inhibitor (Pan) | Dasatinib | Preclinical - Biochemical | Actionable | In a preclinical study, Sprycel (dasatinib) treatment inhibited Pdgfrb activity in a reporter assay in a cell line expressing PDGFRB D850Y (PMID: 39580648). | 39580648 |