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Molecular Profile ATM negative
Therapy ART0380 + Irinotecan
Indication/Tumor Type Advanced Solid Tumor
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ATM negative Advanced Solid Tumor predicted - sensitive ART0380 + Irinotecan Phase Ib/II Actionable In a Phase I/II trial, treatment with the combination of Camptosar (irinotecan) and ART0380 in patients with advanced solid tumors was well tolerated and resulted in an objective response rate of 23% (13/57) overall, 45% (9/20) in ATM negative patients, 22% (4/18) with low ATM expression, and 0% (0/13) with high ATM expression (Cancer Res (2025) 85 (8_Supplement_2): CT267; NCT04657068). detail...
PubMed Id Reference Title Details
Abstract CT267: First results of ART0380 (an ATR kinase inhibitor) with low dose irinotecan in advanced or metastatic solid tumors Full reference...