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Therapy Name ART0380 + Irinotecan
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ART0380 ART-0380|ART 0380 ATR Inhibitor 16 ART0380 inhibits ATR activity leading to decreased phopshorylation of Chk1, which may result in impaired DNA damage repair, induction of apoptosis in tumor cells, and antitumor activity (NCI Drug Dictionary, (Ann Oncol 34 (2023): S475-S476).
Irinotecan Camptosar CPT-11 TOPO1 inhibitor 11 Camptosar (irinotecan) inhibits Topoisomerase-I activity, resulting in inhibition of DNA replication, and potentially leading to cell death and is indicated as a component of first-line therapy in combination with 5-fluorouracil and leucovorin for patients with metastatic or recurrent colorectal carcinoma (FDA.gov).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ATM negative Advanced Solid Tumor predicted - sensitive ART0380 + Irinotecan Phase Ib/II Actionable In a Phase I/II trial, treatment with the combination of Camptosar (irinotecan) and ART0380 in patients with advanced solid tumors was well tolerated and resulted in an objective response rate of 23% (13/57) overall, 45% (9/20) in ATM negative patients, 22% (4/18) with low ATM expression, and 0% (0/13) with high ATM expression (Cancer Res (2025) 85 (8_Supplement_2): CT267; NCT04657068). detail...

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04657068 Phase Ib/II ART0380 + Gemcitabine ART0380 + Irinotecan ART0380 Gemcitabine A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors Recruiting USA | GBR | FRA | ESP 0


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