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| Molecular Profile | RET G810S |
| Therapy | Zeteletinib |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| RET G810S | Advanced Solid Tumor | predicted - sensitive | Zeteletinib | Preclinical - Cell culture | Actionable | In a preclinical study, cells expressing RET G810S in the context of KIF5B-RET were sensitive to Zeteletinib (DS-5010) treatment in culture (Cancer Res (2024) 84 (6_Supplement): 5833). | detail... |
| PubMed Id | Reference Title | Details |
|---|---|---|
| Abstract 5833: Genomic mechanisms of RET inhibitor resistance in RET-fusion positive NSCLC | Full reference... |