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| Molecular Profile | BARD1 R112* |
| Therapy | Olaparib |
| Indication/Tumor Type | neuroblastoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BARD1 R112* | neuroblastoma | sensitive | Olaparib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Lynparza (olaparib) treatment inhibited viability of a neuroblastoma cell line expressing BARD1 R112* in culture and inhibited tumor growth in a cell line xenograft model (PMID: 37688570). | 37688570 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (37688570) | BARD1 germline variants induce haploinsufficiency and DNA repair defects in neuroblastoma. | Full reference... |